genetic background – Communicable Diseases Research

Epistasis-Driven Evolution of the SARS-CoV-2 Secondary Structure

Article

Published on 2022-12-012022-11-16
Journal: Journal of molecular evolution
[Category] COVID19(2023년), SARS, 변종,

Genetic variants determine intrafamilial variability of SARS-CoV-2 clinical outcomes in 19 Italian families

Article

Published on 2022-10-132022-11-15
Journal: PLoS ONE
[Category] COVID19(2023년), SARS, 변종, 치료기술,

Probing SARS-CoV-2-positive plasma to identify potential factors correlating with mild COVID-19 in Ghana, West Africa

Article

Published on 2022-10-032022-11-15
Journal: BMC Medicine
[Category] COVID19(2023년), SARS, 바이오마커,

[키워드] ABO ABO blood grouping ABO blood groups acute respiratory syndrome African anti-SARS-CoV-2 antibody antibodies antibody association Asymptomatic Asymptomatic case Blood Blood Group Clustering comparison Concentration coronavirus coronavirus disease correlations COVID-19 COVID-19 severity cytokine cytokine level decrease discrepancy disease severity Eotaxin Factor genetic background group groups Host identify IL-6 IL-8 immune marker Immune profile immune response individuals Kruskal-Wallis Mann-Whitney U test Mild Multiple Multiplex assay offer participant PCR-confirmed performed phenotype plasma Probing proportion quantification recorded reduced regression analysis significantly Spearman statistically significant symptomatic symptomatic and asymptomatic symptomatic patient tested two-tailed was performed was used West West Africa.
[DOI] 10.1186/s12916-022-02571-2 PMC 바로가기

Functional associations between polymorphic regions of the human 3’IgH locus and COVID-19 disease

인간 3'IgH 유전자좌의 다형성 영역과 COVID-19 질병 간의 기능적 연관성

Article

Published on 2022-09-052022-09-11
Journal: Gene
[Category] COVID19(2023년), SARS, 변종,

[키워드] age allele allelic Allelic polymorphisms Alpha association blood sample Blood samples Clinical outcome clinical outcomes Clinical severity collected coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients diffusion disease severity disequilibrium distribution DNA binding enhancer enhancer region ERα Estrogen Estrogen receptor alpha exhibited explain Genetic genetic background Genetic variant genetic variants genotyped SNP genotyped SNPs haplotypes heavy chain hospital hs1,2 enhancer. humans hypothese IgH locus immune response Immunoglobulin Infection Italy less linkage locus men MOST nine nucleotide Occurrence pandemic Pneumonia produced protective factor receptor Region SARS-COV-2 infection severe disease sex differences Sex-related differences significantly SNPs women
[DOI] 10.1016/j.gene.2022.146698 PMC 바로가기 [Article Type] Article

The structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation

스파이크 돌연변이의 출현과 성공에서 SARS-CoV-2 유전적 배경의 구조적 역할: 스파이크 A222V 돌연변이의 경우

Article

Published on 2022-07-112022-09-11
Journal: PLoS Pathogens
[Category] COVID19(2023년), SARS, 변종,

Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera

쥐 감염 및 인간 면역 혈청 탈출에 중요한 SARS-CoV-2 스파이크 돌연변이의 특성화

Article

Published on 2022-07-072022-09-11
Journal: Nature Communications
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

[키워드] (alpha ACE-2 Alpha angiotensin angiotensin converting enzyme B.1.1.529 B.1.1.7 B.1.351 Beta cause characterization convalescent disease Efficiency enzyme Gamma genetic background H655Y immune infect Infection insertion Lineage lineages lung mice Mild Mild disease morbidity murine Mutation N genes N501Y neutralization not affect obese omicron Omicron variants P.1 post vaccination receptor Receptor binding domain S gene S protein SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 isolates SARS-CoV-2 Spike mutation SARS-CoV-2 variant SARS-CoV-2 variants sera Transmissibility USA-WA1/2020 variants virus viruses VOCs wild type
[DOI] 10.1038/s41467-022-30763-0 PMC 바로가기 [Article Type] Article

Infliximab treatment for refractory COVID-19-associated multisystem inflammatory syndrome in a Japanese child

일본 어린이의 불응성 COVID-19 관련 다기관 염증 증후군에 대한 Infliximab 치료

Article

Published on 2022-06-012022-09-12
Journal: Journal of infection and chemotherapy : official j
[Category] COVID19(2023년), MERS, SARS, 진단, 치료법,

[키워드] Administered Asia Aspirin children circulating ferritin clinical feature clinical phenotype Clinical symptoms Cohort coronavirus disease COVID-19 develop diagnosed East extreme genetic background heterogeneous Hyperferritinemia hyperinflammation Immunopathogenesis immunopathology IMPROVE incidence induce Inflammation Inflammatory infliximab initial Intervention Intravenous immunoglobulin Japan Japanese Kawasaki disease lymphopenia MIS-C multisystem inflammatory syndrome in children. onset of fever outcome Pathogenesis Patient Prednisolone Region reported required Symptom syndrome Therapies therapy treated Treatment treatment strategy tumor necrosis factor-α
[DOI] 10.1016/j.jiac.2022.01.011 PMC 바로가기 [Article Type] Article

Assessment of NKG2C copy number variation in HIV-1 infection susceptibility, and considerations about the potential role of lacking receptors and virus infection

Research

Published on 2022-03-222022-10-05
Journal: Journal of Human Genetics
[Category] 유전자 메커니즘,

Evaluation of the genetic risk for COVID-19 outcomes in COPD and differences among worldwide populations

Research Article

Published on 2022-02-232022-10-28
Journal: PLoS ONE
[Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] acute respiratory syndrome African allele alleles allelic allelic combination Analysis Asian build Case-control characterized chronic obstructive clinical response clinically Cohort conducted contributing to control group COPD coronavirus COVID-19 COVID-19 infection COVID-19 susceptibility Diseases distribution European European population finding Frequency Genetic genetic background genetic heterogeneity genetic map Genetic predisposition genetic risk genotyped global pandemic groups heterogeneity Hospitalization Infection Italian outcome P-value people with COPD Phenotypes poor prognosis Population populations predisposition Probability Prognosis pulmonary disease recent Respiratory failure respond risk risk allele Risk scores rs657152 Saliva severe COVID-19 severity significant difference SNP Spanish survival susceptibility used to calculate Variability was performed were assessed
[DOI] 10.1371/journal.pone.0264009 PMC 바로가기 [Article Type] Research Article

ACE and ACE2 Gene Variants Are Associated With Severe Outcomes of COVID-19 in Men

ACE 및 ACE2 유전자 변이는 남성의 심각한 COVID-19 결과와 관련이 있습니다

Immunology

Published on 2022-02-172022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] ACE ACE2 95%CI ACE ACE2 ACE2 gene acute respiratory syndrome acute respiratory syndrome coronavirus addition adjusted affecting age association clinical manifestation clinical manifestations Clinical manifestations of COVID-19 coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 Critical Critical illness death develop diabetes diagnosed died disease severity DNA evaluated explain Factor genetic background Genetic variant genetic variants Genomic DNA Genotype genotyped High-resolution Host hypertension IMPROVE individual insertion/deletion involved Logistic regression analysis male men Mild obesity Odds ratio outcome outcomes oxygen oxygen supplementation pandemic Peripheral blood polymorphism Polymorphisms probes respiratory respond responsible reverse transcription PCR risk factor rs2285666 RT-PCR Saliva SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity severity of COVID-19 Sex single-nucleotide single-nucleotide polymorphism SNP study population T allele TaqMan type 2 diabetes Variability variant
[DOI] 10.3389/fimmu.2022.812940 PMC 바로가기 [Article Type] Immunology